Researchers from Rochester Regional Health used graded doses to successfully administer a second dose of the Moderna vaccine to two patients who had an immediate hypersensitivity reaction with the first dose. Their case report is published today in Annals of Internal Medicine.

The first patient, a 64-year-old woman with a history of shellfish allergy, received dose one of the Moderna vaccine and experienced skin irritation, hives, and a rapid heartbeat within 10 minutes. She was treated successfully by medical personnel at the vaccination site. Patient 2, a 39-year-old woman with a history of allergic rhinitis, received dose one of the Moderna vaccine and developed hives on her chest and neck within 15 minutes. Medical personnel treated her symptoms at the vaccination site, but she went on to develop mild facial swelling and was transported by ambulance to the emergency department. After brief treatment, her symptoms resolved and she was discharged to home in stable condition.

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